Bradley Denker

Brad Denker graduated from State University of New York Medical School in Syracuse, NY, and completed his internal medicine residency at the Johns Hopkins Hospital in Baltimore, Maryland. He did a one-year Fellowship in Hematology at Johns Hopkins in the laboratory of Dr. Peter Agre and was the lead author on the paper that ultimately led to the discovery of Aquaporins (2003 Nobel Prize). He did his Nephrology Fellowship at the Brigham and Women’s Hospital. He moved to BIDMC in 2011, and he supervised a basic research laboratory in the Renal Division until 2012 where his work focused on cell signaling in epithelial cells and the role of G proteins in Acute Kidney Injury and Polycystic Kidney Disease. He is the past president of the Medical Advisory Board for the National Kidney Foundation serving New England and has authored numerous chapters and textbooks on kidney disease, including the Renal Pathophysiology, The Essentials with Dr. Helmut Rennke. He lectures regularly at internal medicine and nephrology CME courses on chronic kidney disease, fluids and electrolytes, acute renal failure and hypertension. In addition to his clinical and administrative duties at BIDMC, he also serves as the Chief of Nephrology and the Associate Chief of Medical Specialties at Harvard Vanguard Medical Associates (Atrius), where he continues to study how electronic medical records are used to improve recognition and management of chronic kidney disease as well as the development of new care delivery models to improve quality and reduce costs in the dialysis patient population.

Education:

Suny Health Science Center , 1984, MD

Publications

1. Sequist TD, Holliday AM, Orav EJ, Bates DW, Denker BM. Physician and patient tools to improve chronic kidney disease care. Am J Manag Care. 2018 04 01; 24(4):e107-e114.

2. Wu Y, Xu JX, El-Jouni W, Lu T, Li S, Wang Q, Tran M, Yu W, Wu M, Barrera IE, Bonventre JV, Zhou J, Denker BM, Kong T. Ga12 is required for renal cystogenesis induced by Pkd1 inactivation. J Cell Sci. 2016 10 01; 129(19):3675-3684.

3. Ismail OZ, Zhang X, Wei J, Haig A, Denker BM, Suri RS, Sener A, Gunaratnam L. Kidney injury molecule-1 protects against Ga12 activation and tissue damage in renal ischemia-reperfusion injury. Am J Pathol. 2015 May; 185(5):1207-15.

4. Xu JX, Lu TS, Li S, Wu Y, Ding L, Denker BM, Bonventre JV, Kong T. Polycystin-1 and Ga12 regulate the cleavage of E-cadherin in kidney epithelial cells. Physiol Genomics. 2015 Feb; 47(2):24-32.

5. Barski JJ, Denker BM, Guan J, Lauth M, Spreafico F, Fertala A, Meyer M. Developmental upregulation of an alternative form of pcp2 with reduced GDI activity. Cerebellum. 2014 Apr; 13(2):207-14.

6. Yu W, Beaudry S, Negoro H, Boucher I, Tran M, Kong T, Denker BM. H2O2 activates G protein, a 12 to disrupt the junctional complex and enhance ischemia reperfusion injury. Proc Natl Acad Sci U S A. 2012 Apr 24; 109(17):6680-5.

7. Boucher I, Yu W, Beaudry S, Negoro H, Tran M, Pollak MR, Henderson JM, Denker BM. Ga12 activation in podocytes leads to cumulative changes in glomerular collagen expression, proteinuria and glomerulosclerosis. Lab Invest. 2012 May; 92(5):662-75.

8. Denker B, Robles-Osorio ML, Sabath E. Recent advances in diagnosis and treatment of acute kidney injury in patients with cancer. Eur J Intern Med. 2011 Aug; 22(4):348-54.

9. Denker BM, Sabath E. The biology of epithelial cell tight junctions in the kidney. J Am Soc Nephrol. 2011 Apr; 22(4):622-5.

10. Dowal L, Sim DS, Dilks JR, Blair P, Beaudry S, Denker BM, Koukos G, Kuliopulos A, Flaumenhaft R. Identification of an antithrombotic allosteric modulator that acts through helix 8 of PAR1. Proc Natl Acad Sci U S A. 2011 Feb 15; 108(7):2951-6.