Dennis Kappei

Education

• Doctor of Philosophy (Ph.D.) Technische Universität Dresden (2007 — 2013)
• Master’s Degree Ecole normale supérieure (2005 — 2007)
• Bachelor’s Degree Leipzig University (2003 — 2005)

Companies

• Assistant Professor National University of Singapore (2019)
• Principal Investigator National University of Singapore (2018)
• Special Fellow National University of Singapore (2015 — 2018)
• PhD Student Max Planck Institute of Molecular Cell Biology and Genetics (2007 — 2013)

Skills

• Science
• Genetics
• Proteomics

Other

Molecular Biology, Cell Biology

Selected Publications

• Bluhm A., Viceconte N., Li F., Rane G., Ritz S., Wang S., Levin M., Shi Y., Kappei D.#, Butter F.# (2019) ZBTB10 binds the telomeric variant repeat TTGGGG and interacts with TRF2. Nucleic Acids Research 47(4): 1896-1907.
• Tay L.S., Krishnan V., Sankar H., Chong Y.L., Chuang L.S.H. Tan T.Z., Kolinjivadi A.M., Kappei D., Ito Y. (2018) RUNX Poly(ADP-Ribosyl)ation and BLM Interaction Facilitate the Fanconi Anemia Pathway of DNA Repair. Cell Reports 24(7): 1747-1755.
• Jahn A., Rane G., Paszkowski-Rogacz M., Sayols S., Bluhm A., Han C.T., Draškovič I., Londoño-Vallejo J.A., Kumar A.P., Buchholz F.#, Butter F.#, Kappei D.# (2017) ZBTB48 is both a vertebrate telomere-binding protein and a transcriptional activator. EMBO Reports 18(6): 929-946.
• Rajagopalan D., Pandey A.K., Xiuzhen M.C., Lee K.K., Hora S., Zhang Y., Chua B.H., Kwok H.S., Bhatia S.S., Deng L.W., Tenen D.G., Kappei D., Jha S. (2017) TIP60 represses telomerase expression by inhibiting Sp1 binding to the TERT promoter. PLoS Pathogens: e1006681.
• Kappei D., Scheibe M., Paszkowski-Rogacz M., Bluhm A., Gossmann T.I., Dietz S., Dejung M., Herlyn H., Buchholz F.#, Mann M.#, Butter F.# (2017) Phylointeractomics reconstructs functional evolution of protein binding. Nature Communications 8: 14334.
• Casa-Vila N., Scheibe M., Freiwald A., Kappei D., Butter F. (2015) Identification of TTAGGG-binding proteins in Neurospora crassa, a fungus with vertebrate-like telomere repeats. BMC Genomics 16(1): 965.
• Machyna M., Kehr S., Straube K., Kappei D., Buchholz F., Butter F., Ule J., Hertel J., Stadler P., Neugebauer K. (2014) The coilin interactome identifies hundreds of small noncoding RNAs that traffic through Cajal bodies. Molecular Cell 56(3): 389-399.
• Scheibe M., Arnoult N., Kappei D., Buchholz F., Decottignies A., Butter F.#, Mann M.# (2013) Quantitative interaction screen of telomeric repeat-containing RNA reveals novel TERRA regulators. Genome Research 23(12): 2149-2157.
• Kappei D., Butter F., Benda C., Scheibe M., Draškovič I., Stevense M., Novo C.L., Basquin C., Araki M., Araki K., Krastev D.B., Kittler R., Jessberger R., Londoño-Vallejo J.A., Mann M.#, Buchholz F.# (2013) HOT1 is a mammalian direct telomere repeat-binding protein contributing to telomerase recruitment. EMBO Journal 32(12): 1681-1701
• Chakraborty D., Kappei D., Theis M., Nitzsche A., Ding L., Paszkowski-Rogacz M., Surendranath V., Berger N., Schulz H., Saar K., Hubner N., Buchholz F. (2012) Combined RNAi and localization for functionally dissecting long noncoding RNAs. Nature Methods 9(4): 360-362.