Gloryn Chia

Dr Chia is a National Research Foundation fellow (Class of 2020) and L'Oréal-UNESCO for Women in Science National Fellowship finalist. She received her Ph.D. in Stem Cell Biology from the University of Cambridge under the Wellcome Trust PhD scholarship and subsequently did her postdoctoral training at Columbia University under the A*STAR International Fellowship.

Upon returning to Singapore, Dr Chia continued her research in cell therapy at the Bioprocessing Technology Institute, A*STAR. After her stint in A*STAR, she joined Merck Sharp and Dohme (MSD), Translation Medicine Research Centre, as a senior scientist focusing on discovering and validating targets founded on human genetics in early drug discovery space.

Her research interests include immunotherapy, cell therapy and the use of stem cells for disease modelling and regenerative medicine. She has published in several journals, including Nature, Nature Cell Biology and Development.

Education

• Doctor of Philosophy (Ph.D.) University of Cambridge (2008 — 2012)
• Master of Philosophy - MPhil University of Cambridge (2008 — 2008)
• Bachelor of Science (B.Sc.) National University of Singapore (2003 — 2007)
• Master of Philosophy - MPhil University of Cambridge

Companies

• Assistant Professor National University of Singapore (2019)
• Senior Scientist Merck (2018 — 2019)
• Research fellow A*STAR - Agency for Science, Technology and Research (2016 — 2018)
• Postdoctoral Research Fellow Columbia University in the City of New York (2013 — 2016)

Awards

• 2020 National Research Foundation Fellowship
• 2019 L’Oréal UNESCO for Women in Science Fellowships finalist
• 2018 NMRC Young Individual Research Grant
• 2013 A*STAR International Fellowship
• 2008 Wellcome Trust 4-year PhD Scholarship
• 2008 Cambridge Commonwealth Trust Bursary
• 2009 Overseas Research Award
• 2003-2006 Dean’s list for six consecutive semesters
• 2003-2007 Ngee Ann Kongsi’s Scholarship for four consecutive years

Manuscripts Full-Text (Self-archive)

• Chia G*, Mulas C*, Jones KA, Hodgson AC, Stirparo GG, Nichols J. (2018) Oct4 regulates the embryonic axis and coordinates exit from pluripotency and germ layer specification in the mouse embryo. Development; 145(12). *co-first
• Lee E, Sivalingam J, Lim ZR, Chia G, Shi LG, Roberts M, Loh YH, Reuveny S, Oh SK. (2018) Review: In vitro generation of red blood cells for transfusion medicine: Progress, prospects and challenges. Biotechnol Adv;36(8):2118-2128.
• Chia G, Agudo J, Treff N, Sauer MV, Billing D, Brown BD, Baer R, Egli D (2017). Genomic instability during reprogramming by nuclear transfer is DNA replication dependent. Nat Cell Biol; 19(4):282-291.
• Sagi I, Chia G, Golan-Lev T, Peretz M, Sui L, Sauer M.V., Egli D, Benvenisty N (2016). Derivation and differentiation of haploid human embryonic stem cells. Nature; 7;532(7597):107-11.
• Grossman L. C, Chia G, Zuccaro M, Sadowy S, Prosser R, Sauer M. V., & Egli D (2016). Determination of timing and mechanism of diploidization of haploid parthenogenetic and androgenetic human embryos. Fertility and Sterility; 106(3), e50.
• Chia G*, Kort D*, Tanaka A, Treff N, Vensand L, Micucci S, Prosser R, Lobo R, Sauer M, Egli D (2015). Human embryos commonly form abnormal nuclei during development: a mechanism of DNA damage, embryonic aneuploidy, and developmental arrest. Hum Reprod; 31(2):312-23. *co-first
• Chia Le Bin G, Muñoz-Descalzo S, Kurowski A, Leitch H, Lou X, Mansfield W, Etienne- Dumeau C, Grabole N, Mulas C, Niwa H, Hadjantonakis AK, Nichols J. (2014). Oct4 is required for lineage priming in the developing inner cell mass of the mouse blastocyst. Development; 141(5):1001-10.
• Radzisheuskaya A, Chia Gle B, dos Santos RL, Theunissen TW, Castro LF, Nichols J, Silva JC. (2013). A defined Oct4 level governs cell state transitions of pluripotency entry and differentiation into all embryonic lineages. Nat Cell Biol; 15(6):579-90.
• Livigni A, Peradziryi H, Sharov AA, Chia G, Hammachi F, Migueles RP, Sukparangsi W, Pernagallo S, Bradley M, Nichols J, Ko MS, Brickman JM. (2013) A conserved Oct4/POUV- dependent network links adhesion and migration to progenitor maintenance. Curr Biol; 18;23(22):2233-44.
• Chia G, Egli D (2013). Connecting the cell cycle with cellular identity. Cell Reprogram; 15(5):356-66.
• Egli D, Le Bin GC. (2013). Tying replication to cell identity. Nat Rev Mol Cell Biol; 14(6):326.