Hanry Yu

Research Areas

Cell and Tissue Engineering Laboratory translates the latest biological and engineering knowledge into innovative technologies for diagnostics, therapeutics and drug testing applications in pharmaceutical and healthcare industry.

Research Interests

We adopt the latest industrial management models of teams to train future leaders of the R&D-based industry and academia. Our research expertise span from basic biological studies, biomaterials synthesis, to integrative engineering of biomedical devices that facilitate the translation of systems level understanding of biological functional processes into significant application solutions to help patients with liver diseases; and fuel biomedical industrial development in Asia. We acquire fundamental principles and technologies to quantitatively study and manipulate liver cell and tissue polarity and functions at meso-scale such that their global tissue structures and functions can be precision-engineered at mm-cm scales for applications.

Biography

Prof Yu is a Professor in the Department of Physiology, YLL School of Medicine, National University Health System; Principal Investigator at MBI and Group Leader at the Institute of Bioengineering and Nanotechnology, A STAR. He was trained as a cell biologist but ventured into various other disciplines such as imaging, biomaterials, tissue engineering, drug testing, and computational biology of liver fibrosis. He takes pride in the interdisciplinary approach to research and graduate training; and he strives to build integrated teams to equip future graduates to readily adapt into both industrial and future academic settings.

Recent Publications

• Chia S, Teo G, Tay SJ, Loo LSW, Wan C, Sim LC, Yu H, Walsh I, and Pang KT. An Integrative Glycomic Approach for Quantitative Meat Species Profiling. Foods 2022; 11(13). [PMID: 35804766]
• Tasnim F, Huang X, Lee CZW, Ginhoux F, and Yu H. Recent Advances in Models of Immune-Mediated Drug-Induced Liver Injury. Front Toxicol 2021; 3:605392. [PMID: 35295156]
• Li Z, Chen Z, Gao Y, Xing Y, Zhou Y, Luo Y, Xu W, Chen Z, Gao X, Gupta K, Anbalakan K, Chen L, Liu C, Kong J, Leo HL, Hu C, Yu H, and Guo Q. Shape memory micro-anchors with magnetic guidance for precision micro-vascular deployment. Biomaterials 2022; 283:121426. [PMID: 35240471]
• Wu X, Chan C, Springs SL, Lee YH, Lu TK, and Yu H. A warm-start digital CRISPR/Cas-based method for the quantitative detection of nucleic acids. Anal Chim Acta 2022; 1196:339494. [PMID: 35151407]
• Luo Y, Ma Y, Chen Z, Gao Y, Zhou Y, Liu X, Liu X, Gao X, Li Z, Liu C, Leo HL, Yu H, and Guo Q. Shape-Anisotropic Microembolics Generated by Microfluidic Synthesis for Transarterial Embolization Treatment. Adv Healthc Mater 2022;:e2102281. [PMID: 35106963]
• Yang Y, Nguyen E, Sankara Narayana GHN, Heuzé M, Fu C, Yu H, Mège R, Ladoux B, and Sheetz MP. Local contractions regulate E-cadherin rigidity sensing. Sci Adv 2022; 8(4):eabk0387. [PMID: 35089785]
• Gao X, Chen Z, Chen Z, Liu X, Luo Y, Xiao J, Gao Y, Ma Y, Liu C, Leo HL, Yu H, and Guo Q. Visualization and Evaluation of Chemoembolization on a 3D Decellularized Organ Scaffold. ACS Biomater Sci Eng 2021;. [PMID: 34735119]
• Ong S, Loo L, Pang M, Tan R, Teng Y, Lou X, Chin SK, Naik MY, and Yu H. Decompartmentalisation as a simple color manipulation of plant-based marbling meat alternatives. Biomaterials 2021; 277:121107. [PMID: 34507131]
• Lee F, Shah I, Soong YT, Xing J, Ng IC, Tasnim F, and Yu H. Reproducibility and robustness of high-throughput S1500+ transcriptomics on primary rat hepatocytes for chemical-induced hepatotoxicity assessment. Curr Res Toxicol 2021; 2:282-295. [PMID: 34467220]
• Teng Y, Zhao Z, Tasnim F, Huang X, and Yu H. A scalable and sensitive steatosis chip with long-term perfusion of in situ differentiated HepaRG organoids. Biomaterials 2021; 275:120904. [PMID: 34119888]