Jeffrey Goldsmith

Dr. Jeffery Goldsmith began his career at Beth Israel Deaconess Medical Center as a junior gastrointestinal pathologist, starting in 2003, and began work at Boston Children's Hospital as a pediatric gastrointestinal pathologist. As his career evolved, he began specializing in pediatric GI diseases. Dr. Goldsmith began working at BCH full time in 2016.

Dr. Goldsmith practices pediatric gastrointestinal pathology at Boston Children's Hospital and also serves as the director of the gastrointestinal pathology service. His research interests include the clinicopathologic aspects of pediatric gastrointestinal diseases such as celiac disease, inflammatory bowel disease, eosinophilic gastrointestinal diseases, congenital diarrheal illness, and polyposes.

CERTIFICATIONS

• American Board of Pathology, Anatomic and Clinical Pathology

EDUCATION

Undergraduate Degree

• University of Michigan , 1991 , Ann Arbor , MI

Medical School

• Wayne State University School of Medicine , 1996 , Detroit , MI

Residency

• Anatomic and Clinical Pathology
• University of Pennsylvania Medical Center , 2001 , Philadelphia , PA

Fellowship

• Gastrointestinal; Hepatic and Surgical Pathology
• University of Pennsylvania Medical Center , 2002 , Philadelphia , PA

PUBLICATIONS

• Variants in STXBP3 are Associated with Very Early Onset Inflammatory Bowel Disease, Bilateral Sensorineural Hearing Loss and Immune Dysregulation. J Crohns Colitis. 2021 Nov 08; 15(11):1908-1919.
• Pediatric Collagenous Gastritis: Clinical and Histologic Outcomes in a Large Pediatric Cohort. J Pediatr Gastroenterol Nutr. 2021 10 01; 73(4):513-519.
• Combined immunodeficiency with autoimmunity caused by a homozygous missense mutation in inhibitor of nuclear factor ??B kinase alpha (IKKa). Sci Immunol. 2021 Sep 17; 6(63):eabf6723.
• Cytomegalovirus Colitis in An Immunocompetent Patient. J Pediatr Gastroenterol Nutr. 2021 08 01; 73(2):e47.
• Liver Pathology, Including MOC31 Immunohistochemistry, in Congenital Tufting Enteropathy. Am J Surg Pathol. 2021 08 01; 45(8):1091-1097.
• CD16+CD163+ monocytes traffic to sites of inflammation during necrotizing enterocolitis in premature infants. J Exp Med. 2021 09 06; 218(9).
• Is Asking Questions on Rounds a Teachable Skill?[Response to Letter]. Adv Med Educ Pract. 2021; 12:147-148.
• Novel variants in the stem cell niche factor WNT2B define the disease phenotype as a congenital enteropathy with ocular dysgenesis. Eur J Hum Genet. 2021 06; 29(6):998-1007.
• Is Asking Questions on Rounds a Teachable Skill? A Randomized Controlled Trial to Increase Attendings' Asking Questions. Adv Med Educ Pract. 2020; 11:921-929.
• Evaluating Responses to Gluten Challenge: A Randomized, Double-Blind, 2-Dose Gluten Challenge Trial. Gastroenterology. 2021 02; 160(3):720-733.e8.
• Response to Letter to the Editor on "Columnar Lined Esophagus/Gastric Metaplasia Requires Careful Follow-up". J Pediatr Gastroenterol Nutr. 2020 10; 71(4):e136-e137.
• Daily Dilemmas in Pediatric Gastrointestinal Pathology. Surg Pathol Clin. 2020 Sep; 13(3):399-411.
• Single-Cell Analyses of Colon and Blood Reveal Distinct Immune Cell Signatures of Ulcerative Colitis and Crohn's Disease. Gastroenterology. 2020 08; 159(2):591-608.e10.
• Barrett Esophagus and Intestinal Metaplasia of the Gastroesophageal Junction in Children: A Clinicopathologic Study. J Pediatr Gastroenterol Nutr. 2020 05; 70(5):562-567.
• Estimated Prevalence of Nonverbal Learning Disability Among North American Children and Adolescents. JAMA Netw Open. 2020 04 01; 3(4):e202551.
• Pediatric Collagenous Gastroenterocolitis Successfully Treated with Methotrexate. Case Rep Pediatr. 2020; 2020:1929581.
• Markers of nutritional status and inflammation in transthyretin cardiac amyloidosis: association with outcomes and the clinical phenotype. Amyloid. 2020 Jun; 27(2):73-80.
• Oral viscous mometasone is an effective treatment for eosinophilic esophagitis. J Allergy Clin Immunol Pract. 2020 Mar; 8(3):1107-1109.
• Predictive Markers Require Thorough Analytic Validation. Arch Pathol Lab Med. 2019 08; 143(8):907-909.
• Risk-factors Associated With Poor Outcomes in VEO-IBD Secondary to XIAP Deficiency: A Case Report and Literature Review. J Pediatr Gastroenterol Nutr. 2019 07; 69(1):e13-e18.
• Evaluating the Adoption of Laboratory Practice Guidelines. Arch Pathol Lab Med. 2020 01; 144(1):83-89.
• Papillary haemangioma in the spinal canal of a patient with a germline 12p microdeletion. Histopathology. 2019 07; 75(1):151-153.
• Microscopic/"Backwash" Ileitis and Its Association With Colonic Disease in New Onset Pediatric Ulcerative Colitis. J Pediatr Gastroenterol Nutr. 2019 06; 68(6):835-840.
• Frozen-Section Checklist Implementation Improves Quality and Patient Safety. Am J Clin Pathol. 2019 05 03; 151(6):607-612.
• Mechanical Skin Injury Promotes Food Anaphylaxis by Driving Intestinal Mast Cell Expansion. Immunity. 2019 05 21; 50(5):1262-1275.e4.
• Risk-factors Associated with Poor Outcomes in VEO-IBD Secondary to XIAP Deficiency: A Case Report and Literature Review. J Pediatr Gastroenterol Nutr. 2019 Feb 07.
• Red Spot Lesions in the Duodenal Bulb Are a Highly Specific Endoscopic Sign of Celiac Disease: A Prospective Study. J Pediatr Gastroenterol Nutr. 2019 02; 68(2):251-255.
• Microscopic / "Backwash" Ileitis and its Association with Colonic Disease in New Onset Pediatric Ulcerative Colitis. J Pediatr Gastroenterol Nutr. 2019 Jan 21.
• Clostridium difficile toxins induce VEGF-A and vascular permeability to promote disease pathogenesis. Nat Microbiol. 2019 02; 4(2):269-279.
• A Distinct Esophageal mRNA Pattern Identifies Eosinophilic Esophagitis Patients With Food Impactions. Front Immunol. 2018; 9:2059.
• Sugar-Sweetened Beverage Attitudes and Consumption During the First 1000 Days of Life. Am J Public Health. 2018 12; 108(12):1659-1665.
• Intracranial Dural Parafalcine Chondroma: Case Report and Systematic Review of the Literature. World Neurosurg. 2019 Feb; 122:1-7.
• Intraobserver and Interobserver Variability in the Assessment of Dysplasia in Ampullary Mucosal Biopsies. Am J Surg Pathol. 2018 08; 42(8):1095-1100.
• Multispectral Endoscopy with Light Gating for Early Cancer Detection. IEEE J Sel Top Quantum Electron. 2019 Jan-Feb; 25(1).