Jennifer Palenchar

Education:

• BS, Chemistry, Shippensburg University of Pennsylvania, Shippensburg, PA
• PhD, Biochemistry, University of Delaware, Newark, DE
• American Heart Association Postdoctoral Fellowship, UMDNJ-NJ Medical School, Newark, NJ
• Biology of Parasitism, Marine Biological Laboratory, Woods Hole, MA

Publications:

• Liu W; Das A; Morales R; Banday M; Aris V; Lukac DM; Soteropoulos P;Wah DA; Palenchar J; Bellofatto V. "Chromatin immunoprecipitation and microarray analysis reveal that TFIIB occupies the SL RNA gene promoter region in Trypanosoma brucei chromosomes." Molecular and Biochemical Parasitology, 186, 139-42, 2012.
• Palenchar PM and Palenchar JB. "The Evolution of Metabolic Enzymes in Plasmodium and Trypanosomatids As Compared to Saccharomyces and Schizosaccharomyces." Molecular and Biochemical Parasitology, 184, 13-19, 2012.
• Whitecavage Solnoki, K; Sing, AS; Sofa, CJ; Miller, R; Ogorzalek, P; Penek, HV; Palenchar, JB. "TbENF49 is an Essential TbTFIIB-Interacting Trypanosomatid-Specific Factor." Molecular and Biochemical Parasitology, 181, 94-101, 2012.
• Shah, TD; Hickey, MC; Capasso, KE; Palenchar,JB. "The Characterization of an unusual trypanosome beta-hydroxybutyrate dehydrogenase." Molecular and Biochemical Parasitology, 179, 100-106, 2011.
• Ibrahim BS; Kanneganti N; Rieckhof GE; Das A; Laurents DV; Palenchar JB; Bellofatto V; Wah DA. "Structure of the C-terminal domain of transcription factor IIB from Trypanosoma brucei." Proceedings of the National Academy of Science U.S.A. 106, 13242-7, 2009.
• Banerjee, H; Palenchar, JB; Lukaszewicz, M; Bojarska, E; Stepinski, J; Jemielity, J; Guranowski, A; Wah, D; Darzynkiewicz, E; and Bellofatto, V. "Identification of the HIT-45 protein from Trypanosoma brucei as an FHIT protein/dinucleoside triphosphatase: substrate specificity studies on the recombinant and endogenous proteins." RNA 15, 1554-64, 2009.
• Bellofatto, V; and Palenchar, JB. "RNA interference as a genetic tool in trypanosomes." Methods in Molecular Biology 442, 83-94, 2008.
• Das A, Zhang Q, Palenchar JB, Chatterjee B, Cross GA, Bellofatto V. "Trypanosomal TBP functions with the multisubunit transcription factor tSNAP to direct spliced-leader RNA gene expression." Molecular and Cellular Biology 25, 7314-7322, 2005.
• Palenchar JB, Crocco JM, Colman RF. "The characterization of mutant Bacillus subtilis adenylosuccinate lyases corresponding to severe human adenylosuccinate lyase deficiencies." Protein Science 12, 1694-1705, 2003.
• Palenchar JB, Colman RF. "Characterization of a mutant Bacillus subtilis adenylosuccinate lyase equivalent to a mutant enzyme found in human adenylosuccinate lyase deficiency: asparagine 276 plays an important structural role." Biochemistry 25, 1831-1841, 2003.
• Brosius [Palenchar] JL, Colman RF. "Three subunits contribute amino acids to the active site of tetrameric adenylosuccinate lyase: Lys268 and Glu275 are required." Biochemistry 19, 2217-2226, 2002.
• Brosius [Palenchar] JL, Colman RF. "A key role in catalysis for His89 of adenylosuccinate lyase of Bacillus subtilis." Biochemistry 39, 13336-13343, 2000.