Li Huang

Education

• Research Scientist, Surgery - Duke University
• Research Associate, Chemistry - Vanderbilt University
• Postdoctoral Fellow, Microbiology And Immunoloty - Vanderbilt University
• Ph.D. 1994 - University of North Carolina - Chapel Hill

Grants

• New Non-Nuceleotide Reverse Transcriptase Inhibitors for Drug Resistant HIV Strains awarded by National Institutes of Health 2021 - 2024
• Small Molecule HIV-1 Entry Inhibitor with Novel Mechanisms of Action awarded by National Institutes of Health 2018 - 2021
• Aloperine derivatives as novel anti-influenza agents awarded by National Institutes of Health 2020 - 2021
• Plant Anti-HIV Agents awarded by University of North Carolina - Chapel Hill 2009 - 2020
• Gnidimacrin and its derivatives against HIV-1 latency awarded by CRDF Global 2018 - 2019
• Quinolizidines as Novel HIV-1 Entry Inhibitors awarded by National Institutes of Health 2016 - 2018
• Regulation of PD-1 as a strategy against chronic HIV-1 infection awarded by National Institutes of Health 2013 - 2016
• Betulinic acid derivatives as anti-HIV agents awarded by National Institutes of Health 2006 - 2016
• Small Molecules that Regulate Proteasome Activity awarded by National Institutes of Health 2009 - 2013
• Identification of anti-HIV agent(s) from Sophora Alkaloids awarded by National Institutes of Health 2008 - 2011

Publications

• Asada, Yoshihisa, Kouharu Otsuki, Miki Morooka, Li Huang, Chin-Ho Chen, Kazuo Koike, and Wei Li. “Anti-HIV Macrocyclic Daphnane Orthoesters with an Unusual Macrocyclic Ring from Edgeworthia chrysantha.” J Nat Prod 85, no. 10 (October 28, 2022): 2399–2405.
• Huang, Li, Lei Zhu, Hua Xie, Jeffery Shawn Goodwin, Tanu Rana, Lan Xie, and Chin-Ho Chen. “Quinolizidines as Novel SARS-CoV-2 Entry Inhibitors.” Int J Mol Sci 23, no. 17 (August 25, 2022).
• Zhou, Di, Kouharu Otsuki, Mi Zhang, Gang Chen, Zi-Song Bai, Haotian Yu, Takashi Kikuchi, et al. “Anti-HIV Tigliane-Type Diterpenoids from the Aerial Parts of Wikstroemia lichiangensis.” J Nat Prod 85, no. 6 (June 24, 2022): 1658–64.
• Otsuki, Kouharu, Mi Zhang, Takashi Kikuchi, Minami Tsuji, Miyuko Tejima, Zi-Song Bai, Di Zhou, et al. “Identification of anti-HIV macrocyclic daphnane orthoesters from Wikstroemia ligustrina by LC-MS analysis and phytochemical investigation.” J Nat Med 75, no. 4 (September 2021): 1058–66.
• Dang, Zhao, Lei Zhu, Lan Xie, Kuo-Hsiung Lee, Faisal Malik, Zhijun Li, Li Huang, and Chin-Ho Chen. “Design and Synthesis of Quinolizidine Derivatives as Influenza Virus and HIV-1 Inhibitors.” Curr Med Chem 28, no. 24 (2021): 4995–5003.
• Otsuki, Kouharu, Mi Zhang, Asuka Yamamoto, Minami Tsuji, Miyuko Tejima, Zi-Song Bai, Di Zhou, et al. “Anti-HIV Tigliane Diterpenoids from Wikstroemia scytophylla.” J Nat Prod 83, no. 12 (December 24, 2020): 3584–90.
• Otsuki, Kouharu, Wei Li, Kasumi Miura, Yoshihisa Asada, Li Huang, Chin-Ho Chen, Kuo-Hsiung Lee, and Kazuo Koike. “Isolation, Structural Elucidation, and Anti-HIV Activity of Daphnane Diterpenoids from Daphne odora.” J Nat Prod 83, no. 11 (November 25, 2020): 3270–77.
• Liu, Qingbo, Yung-Yi Cheng, Wei Li, Li Huang, Yoshihisa Asada, Min-Tsang Hsieh, Susan L. Morris-Natschke, Chin-Ho Chen, Kazuo Koike, and Kuo-Hsiung Lee. “Synthesis and Structure-Activity Relationship Correlations of Gnidimacrin Derivatives as Potent HIV-1 Inhibitors and HIV Latency Reversing Agents.” J Med Chem 62, no. 15 (August 8, 2019): 6958–71.
• Wu, Haifeng, Guoxu Ma, Qinwen Yang, Yindi Zhu, Li Huang, Yu Tian, Xiaoming Yang, et al. “Discovery and synthesis of novel beesioside I derivatives with potent anti-HIV activity.” Eur J Med Chem 166 (March 15, 2019): 159–66.
• Liu, Qingbo, Wei Li, Li Huang, Yoshihisa Asada, Susan L. Morris-Natschke, Chin-Ho Chen, Kuo-Hsiung Lee, and Kazuo Koike. “Identification, structural modification, and dichotomous effects on human immunodeficiency virus type 1 (HIV-1) replication of ingenane esters from Euphorbia kansui.” Eur J Med Chem 156 (August 5, 2018): 618–27.