Marito Araki

Short Biography

• 2000 Ph.D. Osaka University Graduate School of Pharmaceutical Sciences
• 2000-2007 Post-Doctoral Fellow, Howard Hughes Medical Institute, Duke University
• 2007-2011 Junior PI, Cancer Science Institute of Singapore (former Oncology Research Institute till 2008), National University of Singapore
• 2011-2019 Associate Professor, Department of Transfusion Medicine and Stem Cell Regulation, Juntendo University Faculty of Medicine
• 2019-Present Senior Associate Professor, Department of Transfusion Medicine and Stem Cell Regulation, Juntendo University Faculty of Medicine

Keywords

• Hematological malignancies
• Myeloproliferative neoplasms
• Calreticulin (CALR)
• JAK2
• Thrombopoietin receptor
• Glycosylation

Main Research Topics and Interests

• Understanding the molecular mechanism of MPN development by mutant CALR
• Understanding the signal transduction of JAK2V617F tyrosine kinase
• Understanding the molecular mechanism of myelofibrosis
• Development of diagnostic tools for hematological malignancies
• Development of novel therapeutic strategies for hematological malignancies

Publications (in English)

Original Articles (34) Review Articles (8) Citation Index (2,601)

Recent Main Publications

• Masubuchi N, Araki M, Yang Y, Hayashi E, Imai M, Edahiro Y, Hironaka Y, Mizukami Y, Kihara Y, Takei H, Nudejima M, Koike M, Ohsaka A, Komatsu N. Mutant calreticulin interacts with MPL in the secretion pathway for activation on the cell surface. Leukemia. 2020;34(2);499-509
• Araki M, Yang Y, Imai M, Mizukami Y, Kihara Y, Sunami Y, Masubuchi N, Edahiro Y, Hironaka Y, Osaga S, Ohsaka A, Komatsu N. Homomultimerization of mutant calreticulin is a prerequisite for MPL binding and activation. Leukemia. 2019;33(1);122-131
• Araki M, Yang Y, Masubuchi N, Hironaka Y, Takei H, Morishita S, Mizukami Y, Kan S, Shirane S, Edahiro Y, Sunami Y, Ohsaka A, Komatsu N. Activation of the thrombopoietin receptor by mutant calreticulin in CALR-mutant myeloproliferative neoplasms. Blood. 2016;127(10);1307-1316