Nicholas Sawyer

Background

• Assistant Professor at Fordham University
• NIH NRSA Postdoctoral Fellow at New York University
• Ph.D. in Molecular Biophysics and Biochemistry from Yale University
• B.Sc. in Biochemistry from Rutgers University

Research Interests

Research in my group aims to synthesize and evaluate molecules that imitate interacting protein surfaces to investigate the sequence-structure-function relationship of protein-protein interactions involved in human health and disease. Such molecules have utility as both probes for understanding essential biological processes and for innovation in drug development.

Selected Publications

Sawyer, N., Arora, P.S. Hydrogen Bond Surrogate Stabilization of β-Hairpins. ACS Chem. Biol., 2018, 13, 2027.

Sawyer, N., Gassaway, B.M., Haimovich, A.D., Isaacs, F.J., Rinehart, J., Regan, L. Designed phosphoprotein recognition in Escherichia coli. ACS Chem. Biol., 2014, 9, 2502.

Chen, J., Sawyer, N., Regan, L. Protein-protein interactions: general trends in the relationship between binding affinity and interfacial buried surface area. Protein Sci., 2013, 22, 510.