Paul Palevsky

Education

• BS, Northwestern University, 1979
• M.D., Northwestern University, 1981

Training

• Intern and Resident, Hospital of the University of Pennsylvania, 1984
• Fellow in Nephrology, University of Pennsylvania School of Medicine, 1988

Research Interest

Dr. Palevsky is Co-Chair of VA PRESERVE study (Prevention of Serious Adverse Events Following Angiography), a multicenter randomized controlled trial that enrolled nearly 5,200 patients to evaluate strategies for the prevention of adverse renal outcomes following radiocontrast administration being conducted at 33 VA study sites in the United States as well as at international sites. A biorepository for analysis of potential biomarkers of kidney injury in nearly 1,000 patients has been created with funding from the NIDDK. Dr. Palevsky is also leading a US consortium that hopes to participate in the multinational Standard versus Accelerated initiation of Renal Replacement Therapy in Acute Kidney Injury (STARRT-AKI) trial. Dr. Palevsky is participating in the PreCISE AKI study, which will be obtaining kidney biopsies from patients with early acute kidney injury as part of the NIDDKs Kidney Precision Medicine Project (KPMP) consortium. Other areas of research include progression of CKD, management of symptoms in patients with CKD and ESRD and implementation of quality improvement in CKD and ESRD.

Clinical Interest

• Acute kidney injury
• Chronic kidney disease
• End-stage kidney disease
• Hemodialysis
• Continuous renal replacement therapy
• Quality improvement

Selected Publications:

• Palevsky PM, Zhang JH, O’Connor TZ, Chertow GM, Crowley ST, Choudhury D, Finkel K, Kellum JA, Paganini E, Schein RMH, Smith MW, Swanson KM, Thompson BT, Vijayan A, Watnick S, Star RA, Peduzzi P. Intensity of renal support critically ill patients with acute kidney injury. New England Journal of Medicine. 2008; 359: 7-20.
• Fried LF, Duckworth W, Zhang JH, O’Connor T, Brophy M, Emanuele N, Huang GD, McCullough PA, Palevsky PM, Seliger S, Warren SR, Peduzzi P for the VA NEPHRON-D Investigators. Design of combination angiotensin receptor blockade and angiotensin converting enzyme inhibitor for treatment of diabetic nephropathy (VA NEPHRON-D). Clinical Journal of the American Society of Nephrology. 2009; 4: 361-368.
• Johansen KL, Smith MW, Unruh ML, Siroka AM, O’Connor TZ, Palevsky PM. Predictors of health utility among 60-day survivors of acute kidney injury in the VA/NIH Acute Renal Failure Trial Network Study. Clinical Journal of the American Society of Nephrology. 2010; 5.
• Sirsawat N, Wen X, Lee MJ, Kong L, Elder M, Carter M, Unruh M, Finkel K, Vijayan A, Ramkumar M, Paganini E, Singbartl K, Palevsky PM, Kellum JA for the BioMaRK Investigators. Urinary biomarkers predict renal recovery in critically ill patients with renal support. Clinical Journal of the American Society of Nephrology. 2011; 6: InPress.
• Fried LF, Emanuele N, Zhang JH, Brophy M, Conner TA, Duckworth W,, Leehey DJ, McCullough PA, O’Connor T, Palevsky PM, Reilly RF, Seliger AL, Warren SR, Watnick S, Peduzzi P, Guarino P, for the VA NEPHRON-D Investigator. Combined angiotensin inhibition for treatment of diabetic nephropathy. New England Journal of Medicine. 2013; 369: 1892-1903.
• Green JA, Mor MK, Shields AM, Sevick MA, Arnold RM, Palevsky PM, Fine MJ, Weisbord SD. Associations of Health Literacy with Dialysis Adherence and Health Resource Utilization in Patients Receiving Chronic Hemodialysis. American Journal of Kidney Disease. 2013; 62: 73-80.
• Palevsky PM, Liu KD, Brophy PD, Chawla LS, Parikh CR, Thakar CV, Tolwani AJ, Waikar SS, Weisbord, SD. KDOQI US Commentary on the 2012 KDIGO Clinical Practice Guideline for Acute Kidney Injury. American Journal of Kidney Diseases. 2013; 61: 649-672.
• Weisbord SD, Gallagher M, Kaufman J, Cass A, Parikh CR, Chertow GM, Shunk KA, McCullough PA, Fine MJ, Mor MK, Lew RA, Huang GD, Conner TA, Brophy MT, Lee J, Soliva S,, Palevsky PM. Prevention of contrast-induced acute kidney injury: A review of published trials and the design of the Prevention of Serious Adverse Events Following Angiography (PRESERVE) trial. Clinical Journal of the American Society of Nephrology. 2013; 8: 1618-1631.
• Kellum JA, Chawla LS, Keener C, Singbartl K, Palevsky PM, Pike FL, Yealy DM, Huang DT, Angus DC. The effects of alternative resuscitation strategies in acute kidney injury patients with septic shock. American Journal of Respiratory and Critical Care Medicine. 2016; 193: 281-287.