Rocco Gogliotti

I am currently an Assistant Professor in the Department of Molecular Pharmacology and Neuroscience at Loyola University Chicago. My training has spanned both industry and academia, which has provided me with a broad scientific background that I utilize to address hypotheses with diverse and innovative methodologies. My long term goals are to use these methodologies to advance translational research by improving our knowledge of the basic science underlying disease, and integrating this mechanistic understanding into rational drug discovery.

SELECTED PUBLICATIONS

• Gogliotti, R. G., and Niswender, C. M. (2019) A Coordinated Attack: Rett Syndrome Therapeutic Development. Trends in pharmacological sciences 40, 233-236
• Joffe, M. E., Santiago, C. I., Stansley, B. J., Maksymetz, J., Gogliotti, R. G., Engers, J. L., Nicoletti, F., Lindsley, C. W., and Conn, P. J. (2019) Mechanisms underlying prelimbic prefrontal cortex mGlu3/mGlu5-dependent plasticity and reversal learning deficits following acute stress. Neuropharmacology 144, 19-28
• Gogliotti, R. G., Fisher, N. M., Stansley, B. J., Jones, C. K., Lindsley, C. W., Conn, P. J., and Niswender, C. M. (2018) Total RNA Sequencing of Rett Syndrome Autopsy Samples Identifies the M4 Muscarinic Receptor as a Novel Therapeutic Target. The Journal of pharmacology and experimental therapeutics 365, 291-300
• Stansley, B. J., Fisher, N. M., Gogliotti, R. G., Lindsley, C. W., Conn, P. J., and Niswender, C. M. (2017) Contextual Fear Extinction Induces Hippocampal Metaplasticity Mediated by Metabotropic Glutamate Receptor 5. Cerebral cortex, 1-14
• Fisher, N. M., Gogliotti, R. G., Vermudez, S. A. D., Stansley, B. J., Conn, P. J., and Niswender, C. M. (2017) Genetic Reduction or Negative Modulation of mGlu7 Does Not Impact Anxiety and Fear Learning Phenotypes in a Mouse Model of MECP2 Duplication Syndrome. ACS chemical neuroscience
• Gogliotti, R. G., Senter, R. K., Fisher, N. M., Adams, J., Zamorano, R., Walker, A. G., Blobaum, A. L., Engers, D. W., Hopkins, C. R., Daniels, J. S., Jones, C. K., Lindsley, C. W., Xiang, Z., Conn, P. J., and Niswender, C. M. (2017) mGlu7 potentiation rescues cognitive, social, and respiratory phenotypes in a mouse model of Rett syndrome. Science translational medicine 9
• Ponnazhagan, R., Harms, A. S., Thome, A. D., Jurkuvenaite, A., Gogliotti, R., Niswender, C. M., Conn, P. J., and Standaert, D. G. (2016) The Metabotropic Glutamate Receptor 4 Positive Allosteric Modulator ADX88178 Inhibits Inflammatory Responses in Primary Microglia. Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology 11, 231-237
• Gogliotti, R. G., Senter, R. K., Rook, J. M., Ghoshal, A., Zamorano, R., Malosh, C., Stauffer, S. R., Bridges, T. M., Bartolome, J. M., Daniels, J. S., Jones, C. K., Lindsley, C. W., Conn, P. J., and Niswender, C. M. (2016) mGlu5 positive allosteric modulation normalizes synaptic plasticity defects and motor phenotypes in a mouse model of Rett syndrome. Human molecular genetics 25, 1990-2004
• Gogliotti, R. G., and Conn, P. J. (2016) Pharmacological Treatments for Autism Spectrum Disorder: Will Emerging Approaches Yield New Treatments? Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 41, 376-377
• Gogliotti, R. G., Cardona, H., Singh, J., Bail, S., Emery, C., Kuntz, N., Jorgensen, M., Durens, M., Xia, B., Barlow, C., Heier, C. R., Plasterer, H. L., Jacques, V., Kiledjian, M., Jarecki, J., Rusche, J., and DiDonato, C. J. (2013) The DcpS inhibitor RG3039 improves survival, function and motor unit pathologies in two SMA mouse models. Human molecular genetics 22, 4084-4101
• Gogliotti, R. G., Quinlan, K. A., Barlow, C. B., Heier, C. R., Heckman, C. J., and Didonato, C. J. (2012) Motor neuron rescue in spinal muscular atrophy mice demonstrates that sensory-motor defects are a consequence, not a cause, of motor neuron dysfunction. The Journal of neuroscience : the official journal of the Society for Neuroscience 32, 3818-3829
• Gogliotti, R. G., Lutz, C., Jorgensen, M., Huebsch, K., Koh, S., and Didonato, C. J. (2011) Characterization of a commonly used mouse model of SMA reveals increased seizure susceptibility and heightened fear response in FVB/N mice. Neurobiology of disease 43, 142-151
• Kular, R. K., Gogliotti, R. G., and Opal, P. (2010) Cpd-1 null mice display a subtle neurological phenotype. PloS one 5
• Hammond, S. M., Gogliotti, R. G., Rao, V., Beauvais, A., Kothary, R., and DiDonato, C. J. (2010) Mouse survival motor neuron alleles that mimic SMN2 splicing and are inducible rescue embryonic lethality early in development but not late. PloS one 5, e15887
• Gogliotti, R. G., Hammond, S. M., Lutz, C., and Didonato, C. J. (2010) Molecular and phenotypic reassessment of an infrequently used mouse model for spinal muscular atrophy. Biochemical and biophysical research communications 391, 517-522
• Gavrilina, T. O., McGovern, V. L., Workman, E., Crawford, T. O., Gogliotti, R. G., DiDonato, C. J., Monani, U. R., Morris, G. E., and Burghes, A. H. (2008) Neuronal SMN expression corrects spinal muscular atrophy in severe SMA mice while muscle-specific SMN expression has no phenotypic effect. Human molecular genetics 17, 1063-1075
• Heier, C. R., Gogliotti, R. G., and DiDonato, C. J. (2007) SMN transcript stability: could modulation of messenger RNA degradation provide a novel therapy for spinal muscular atrophy? Journal of child neurology 22, 1013-1018
• Wang, X., Gargalovic, P., Wong, J., Gu, J. L., Wu, X., Qi, H., Wen, P., Xi, L., Tan, B., Gogliotti, R., Castellani, L. W., Chatterjee, A., and Lusis, A. J. (2004) Hyplip2, a new gene for combined hyperlipidemia and increased atherosclerosis. Arteriosclerosis, thrombosis, and vascular biology 24, 1928-1934