Alfred Lee

EDUCATION & TRAINING

• MD Yale School of Medicine (2004)
• PhD Yale University (2003)
• Chief Medical Resident Brigham & Women's Hospital
• Fellowship Dana Farber Cancer Institute
• Residency Brigham & Women's Hospital

HONORS & RECOGNITION

Fred Kantor Teacher of the Year Award Yale Internal Medicine Traditional Residency Program (2018)

Inspiring Yale Award Yale University Graduate & Professional Student Senate (2018)

Leah M. Lowenstein Award for excellence in the promotion of humane and egalitarian medical education Yale School of Medicine (2017)

Connecticut Top Doc Connecticut Magazine (2017)

Charles W. Bohmfalk Prize for teaching in the basic sciences Yale School of Medicine (2016)

David S. Fisher Annual Award for outstanding teaching and mentoring of fellows in Hematology Yale Cancer Center (2015)

US News & World Report Top Doctors, Hematology Castle Connolly (2013)

David S. Fischer Annual Award for outstanding teaching and mentoring of fellows in Hematology Yale Cancer Center (2012)

Faculty Teacher of the Year Award Yale Internal Medicine Traditional Residency Program (2012)

PROFESSIONAL SERVICE

ClinGen Hemostasis/Thrombosis Expert Panel (2019 - Present) Member

Recruitment & Retention Working Group, American Society of Hematology (ASH) (2017 - Present) Chair

ASH Committee on Training (2015 - Present) Member

National Comprehensive Cancer Network (NCCN) Cancer-Associated Venous Thromboembolic Disease Panel (2015 - Present) Member

RESEARCH ORGANIZATIONS

Internal Medicine: Hematology

Yale Cancer Center

Office of Cooperative Research

SELECTED PUBLICATIONS

An Update on the "Novel" and Direct Oral Anticoagulants, and Long-Term Anticoagulant Therapy. Djulbegovic M, Lee AI. An Update on the "Novel" and Direct Oral Anticoagulants, and Long-Term Anticoagulant Therapy. Clinics In Chest Medicine 2018, 39:583-593. 2018

Evaluation of Polycythemia: A Teachable Moment. Djulbegovic M, Dugdale LS, Lee AI. Evaluation of Polycythemia: A Teachable Moment. JAMA Internal Medicine 2018, 178:128-130. 2018

Whole-exome sequencing in evaluation of patients with venous thromboembolism. Lee EJ, Dykas DJ, Leavitt AD, Camire RM, Ebberink E, García de Frutos P, Gnanasambandan K, Gu SX, Huntington JA, Lentz SR, Mertens K, Parish CR, Rezaie AR, Sayeski PP, Cromwell C, Bar N, Halene S, Neparidze N, Parker TL, Burns AJ, Dumont A, Yao X, Chaar CIO, Connors JM, Bale AE, Lee AI. Whole-exome sequencing in evaluation of patients with venous thromboembolism. Blood Advances 2017, 1:1224-1237. 2017

CLINICAL PROBLEM-SOLVING. The Hidden Lesion. Lee AI, Ochoa Chaar CI. CLINICAL PROBLEM-SOLVING. The Hidden Lesion. The New England Journal Of Medicine 2016, 374:2160-5. 2016

Clinical problem-solving. Venting the spleen. Varughese N, Duong A, Emre S, Xu M, Lee AI. Clinical problem-solving. Venting the spleen. The New England Journal Of Medicine 2013, 369:1357-63. 2013

Clinical significance of coagulation studies in predicting response to activated recombinant Factor VII in cardiac surgery patients. Lee AI, Campigotto F, Rawn JD, Neuberg D, Kaufman RM, Berliner N. Clinical significance of coagulation studies in predicting response to activated recombinant Factor VII in cardiac surgery patients. British Journal Of Haematology 2012, 157:397-400. 2012

Clinical problem-solving. A bird's-eye view of fever. Lee AI, Koo S, Vaidya A, Katz JT, Loscalzo J. Clinical problem-solving. A bird's-eye view of fever. The New England Journal Of Medicine 2011, 365:1727-32. 2011

Anemia in pregnancy. Lee AI, Okam MM. Anemia in pregnancy. Hematology/oncology Clinics Of North America 2011, 25:241-59, vii. 2011

Transfusion medicine and the pregnant patient. Lee AI, Kaufman RM. Transfusion medicine and the pregnant patient. Hematology/oncology Clinics Of North America 2011, 25:393-413, ix. 2011

A functional analysis of the spacer of V(D)J recombination signal sequences. Lee AI, Fugmann SD, Cowell LG, Ptaszek LM, Kelsoe G, Schatz DG. A functional analysis of the spacer of V(D)J recombination signal sequences. PLoS Biology 2003, 1:E1. 2003

A temperature-sensitive trpS mutation interferes with trp RNA-binding attenuation protein (TRAP) regulation of trp gene expression in Bacillus subtilis. Lee AI, Sarsero JP, Yanofsky C. A temperature-sensitive trpS mutation interferes with trp RNA-binding attenuation protein (TRAP) regulation of trp gene expression in Bacillus subtilis. Journal Of Bacteriology 1996, 178:6518-24. 1996

FULL LIST OF PUBMED PUBLICATIONS

• Hsu C, Brahmandam A, Brownson KE, Huynh N, Reynolds J, Lee AI, Fares WH, Ochoa Chaar CI: Statin therapy associated with improved thrombus resolution in patients with deep vein thrombosis. J Vasc Surg Venous Lymphat Disord. 2019 Mar; 2019 Jan 16. PMID: 30660579
• Djulbegovic M, Lee AI: An Update on the "Novel" and Direct Oral Anticoagulants, and Long-Term Anticoagulant Therapy. Clin Chest Med. 2018 Sep. PMID: 30122182
• Erben Y, Miller SM, Sumpio BJ, Dillon BJ, Lee AI, Blume P, Sumpio BE, Mena-Hurtado C: Acute Limb Ischemia in an 8-Year-Old Patient: A Case Report. Ann Vasc Surg. 2018 Aug; 2018 Apr 13. PMID: 29655809
• Huynh N, Fares WH, Lee AI, Dardik A, Sarac T, Ochoa Chaar CI: Reply. J Vasc Surg Venous Lymphat Disord. 2018 Jul. PMID: 29909864
• Marshall AL, Jenkins S, Oxentenko AS, Lee AI, Siegel MD, Katz JT, Vyas JM, Del Valle J, Mikhael JR: Internal medicine trainees' knowledge and confidence in using the American Society of Hematology Choosing Wisely guidelines in hemostasis, thrombosis, and non-malignant hematology. PLoS One. 2018; 2018 May 16. PMID: 29768480
• Kaltenmeier CT, Erben Y, Indes J, Lee A, Dardik A, Sarac T, Ochoa Chaar CI: Systematic review of May-Thurner syndrome with emphasis on gender differences. J Vasc Surg Venous Lymphat Disord. 2018 May; 2017 Dec 28. PMID: 29290600
• Huynh N, Fares WH, Brownson K, Brahmandam A, Lee AI, Dardik A, Sarac T, Ochoa Chaar CI: Risk factors for presence and severity of pulmonary embolism in patients with deep venous thrombosis. J Vasc Surg Venous Lymphat Disord. 2018 Jan; 2017 Oct 23. PMID: 29074107
• Djulbegovic M, Dugdale LS, Lee AI: Evaluation of Polycythemia: A Teachable Moment. JAMA Intern Med. 2018 Jan 1. PMID: 29131894
• Brownson KE, Brahmandam A, Huynh N, Reynolds J, Fares WH, Lee AI, Dardik A, Ochoa Chaar CI: Characteristics of provoked deep venous thrombosis in a tertiary care center. J Vasc Surg Venous Lymphat Disord. 2017 Jul; 2017 May 9. PMID: 28623981
• Lee EJ, Dykas DJ, Leavitt AD, Camire RM, Ebberink E, García de Frutos P, Gnanasambandan K, Gu SX, Huntington JA, Lentz SR, Mertens K, Parish CR, Rezaie AR, Sayeski PP, Cromwell C, Bar N, Halene S, Neparidze N, Parker TL, Burns AJ, Dumont A, Yao X, Chaar CIO, Connors JM, Bale AE, Lee AI: Whole-exome sequencing in evaluation of patients with venous thromboembolism. Blood Adv. 2017 Jul 11; 2017 Jun 29. PMID: 29296762
• King B, Lee AI, Choi J: Treatment of Hypereosinophilic Syndrome with Cutaneous Involvement with the JAK Inhibitors Tofacitinib and Ruxolitinib. J Invest Dermatol. 2017 Apr; 2016 Nov 22. PMID: 27887955
• Pine AB, Lee EJ, Sekeres M, Steensma DP, Zelterman D, Prebet T, DeZern A, Komrokji R, Litzow M, Luger S, Stone R, Erba HP, Garcia-Manero G, Lee AI, Podoltsev NA, Barbarotta L, Kasberg S, Hendrickson JE, Gore SD, Zeidan AM: Wide variations in blood product transfusion practices among providers who care for patients with acute leukemia in the United States. Transfusion. 2017 Feb; 2016 Nov 22. PMID: 27878822
• Lee EJ, Lee AI: Thrombocytopenia. Prim Care. 2016 Dec. PMID: 27866576
• Lee AI, Tormey CA: The Hidden Lesion. N Engl J Med. 2016 Sep 22. PMID: 27653584
• Lee AI, Ochoa Chaar CI: CLINICAL PROBLEM-SOLVING. The Hidden Lesion. N Engl J Med. 2016 Jun 2. PMID: 27248622
• Stahl M, Mohareb AM, Lee AI, Federman DG, Siddon AJ, Spelman J: Multi-system complications of hypereosinophilia. Am J Hematol. 2016 Jun. PMID: 26700720
• Lee EJ, Smith BD, Merrey JW, Lee AI, Podoltsev NA, Barbarotta L, Litzow MR, Prebet T, Luger SM, Gore S, Streiff MB, Zeidan AM: Patterns of Venous Thromboembolism Prophylaxis During Treatment of Acute Leukemia: Results of a North American Web-Based Survey. Clin Lymphoma Myeloma Leuk. 2015 Dec; 2015 Aug 6. PMID: 26363982
• Streiff MB, Holmstrom B, Ashrani A, Bockenstedt PL, Chesney C, Eby C, Fanikos J, Fenninger RB, Fogerty AE, Gao S, Goldhaber SZ, Hendrie P, Kuderer N, Lee A, Lee JT, Lovrincevic M, Millenson MM, Neff AT, Ortel TL, Paschal R, Shattil S, Siddiqi T, Smock KJ, Soff G, Wang TF, Yee GC, Zakarija A, McMillian N, Engh AM: Cancer-Associated Venous Thromboembolic Disease, Version 1.2015. J Natl Compr Canc Netw. 2015 Sep. PMID: 26358792
• Zhang B, Lee AI, Podoltsev N: Tumor lysis syndrome and acute anemia in an African-American man with chronic lymphocytic leukemia. Oxf Med Case Reports. 2014 Nov; 2014 Nov 7. PMID: 25988058
• Varughese N, Duong A, Emre S, Xu M, Lee AI: Clinical problem-solving. Venting the spleen. N Engl J Med. 2013 Oct 3. PMID: 24088096
• Lee AI, Fugmann SD, Cowell LG, Ptaszek LM, Kelsoe G, Schatz DG: A functional analysis of the spacer of V(D)J recombination signal sequences. PLoS Biol. 2003 Oct; 2003 Oct 13. PMID: 14551903