Cleo Kontoravdi

Cleo Kontoravdi's interests lie in the area of biotechnology, with particular focus on the application of systems engineering principles to bioprocessing.

My research involves the systematic integration of model-based tools, such as sensitivity analysis, design of experiments and optimisation, with experimentation on mammalian cell culture systems. Topics of interest include optimisation of process conditions, controlling protein glycosylation, metabolic flux analysis and multiscale modelling.

I obtained my MEng and PhD in Chemical Engineering from Imperial College London. I then worked as a Research and Development Scientist at Lonza Biologics (Slough, U.K.) before rejoining Imperial as a Lonza/RCUK Fellow in Biopharmaceuticals Processing. I am currently a Senior Lecturer at the Department of Chemical Engineering.

Selected Publications

Journal Articles

• Jimenez del Val I, Kyriakopoulos S, Polizzi KM, et al., 2013, An optimised method for extraction and quantification of nucleotides and nucleotide sugars from mammalian cells, Analytical Biochemistry, Vol:443, Pages:172-180
• Chen N, Koumpouras GC, Polizzi KM, et al., 2012, Genome-based kinetic modeling of cytosolic glucosemetabolism in industrially relevant cell lines -Saccharomyces cerevisiae and Chinese hamsterovary cells, Bioprocess and Biosystems Engineering, Vol:35, Pages:1023-1033
• Kontoravdi C, Pistikopoulos EN, Mantalaris A, 2010, Systematic development of predictive mathematical models for animal cell cultures, Computers & Chemical Engineering, Vol:34, Pages:1192-1198