Michael Klompas

Dr. Klompas works on enhancing public health surveillance using electronic health information in two major spheres: hospital-level surveillance for nosocomial complications and population-level surveillance for infectious diseases and chronic conditions. Dr. Klompas’ hospital level surveillance work is primarily supported by the Centers for Disease Control and Prevention. Under the auspices of the CDC Epicenters he has worked on developing objective, automatable definitions for complications of mechanical ventilation. This work ultimately led to CDC replacing their longstanding definition for ventilator-associated pneumonia with definitions for “ventilator-associated events.” On the population-side, Dr. Klompas and colleagues have enjoyed a long, rich collaboration with local clinical practice groups and the Massachusetts Department of Public Health. The group has collectively developed a surveillance network called “MDPHnet” that a) provides automated detection and electronic case reports for notifiable diseases, b) population-level aggregate surveillance for chronic conditions such as obesity and diabetes, and c) permits health department investigators to initiate novel queries against participating practices’ electronic health record data in a secure and transparent manner.

Publications

Epidemiology of qSOFA Criteria in Undifferentiated Patients and Association with Suspected Infection and Sepsis. (Pubmed Abstract) Authors Anand V, Zhang Z, Kadri SS, Klompas M, Rhee C,

Barriers to the adoption of ventilator-associated events surveillance and prevention. (Pubmed Abstract) Authors Klompas M

Temporal Patterns in Chlamydia Repeat Testing in Massachusetts. (Pubmed Abstract) Authors Dee EC, Hsu KK, Kruskal BA, Menchaca JT, Zambarano B, Cocoros N, Herrick B, Weiss MDP, Hafer E, Erani D, Josephson M, Young J, Torrone EA, Flagg EW, Klompas M

Sepsis Surveillance Using Adult Sepsis Events Simplified eSOFA Criteria Versus Sepsis-3 Sequential Organ Failure Assessment Criteria. (Pubmed Abstract) Authors Rhee C, Zhang Z, Kadri SS, Murphy DJ, Martin GS, Overton E, Seymour CW, Angus DC, Dantes R, Epstein L, Fram D, Schaaf R, Wang R, Klompas M,

Changes in outpatient antibiotic utilization, 2000-2016: More people are receiving fewer antibiotics. (Pubmed Abstract) Authors Cocoros NM, Ochoa A, Klompas M

Does Obesity Protect Against Death in Sepsis? A Retrospective Cohort Study of 55,038 Adult Patients. (Pubmed Abstract) Authors Pepper DJ, Demirkale CY, Sun J, Rhee C, Fram D, Eichacker P, Klompas M, Suffredini AF, Kadri SS

Early Administration of Antibiotics for Suspected Sepsis. (Pubmed Abstract) Authors Mi MY, Klompas M, Evans L

Prevalence, Underlying Causes, and Preventability of Sepsis-Associated Mortality in US Acute Care Hospitals. (Pubmed Abstract) Authors Rhee C, Jones TM, Hamad Y, Pande A, Varon J, O'Brien C, Anderson DJ, Warren DK, Dantes RB, Epstein L, Klompas M,

Tackling the Hospital-Acquired Pneumonia Enrollment Paradox. (Pubmed Abstract) Authors Klompas M

A Comparison of Early, Late, and No Treatment of Intensive Care Unit Delirium With Antipsychotics: A Retrospective Cohort Study. (Pubmed Abstract) Authors Thom RP, Bui MP, Rosner B, Teslyar P, Levy-Carrick NC, Klompas M

Variation in Identifying Sepsis and Organ Dysfunction Using Administrative Versus Electronic Clinical Data and Impact on Hospital Outcome Comparisons. (Pubmed Abstract) Authors Rhee C, Jentzsch MS, Kadri SS, Seymour CW, Angus DC, Murphy DJ, Martin GS, Dantes RB, Epstein L, Fiore AE, Jernigan JA, Danner RL, Warren DK, Septimus EJ, Hickok J, Poland RE, Jin R, Fram D, Schaaf R, Wang R, Klompas M,

Variability in antimicrobial use in pediatric ventilator-associated events. (Pubmed Abstract) Authors Karandikar MV, Coffin SE, Priebe GP, Sandora TJ, Logan LK, Larsen GY, Toltzis P, Gray JE, Klompas M, Sammons JS, Harper MB, Horan K, Lakoma M, Cocoros NM, Lee GM

Antibiotics for Sepsis-Finding the Equilibrium. (Pubmed Abstract) Authors Klompas M, Calandra T, Singer M

Using objective clinical data to track progress on preventing and treating sepsis: CDC's new 'Adult Sepsis Event' surveillance strategy. (Pubmed Abstract) Authors Rhee C, Dantes RB, Epstein L, Klompas M

What Is the Best Treatment for Vancomycin-Resistant Enterococcal Bloodstream Infections? (Pubmed Abstract) Authors Kanjilal S, Kalil AC, Klompas M

Ramelteon is Not Associated With Improved Outcomes Among Critically Ill Delirious Patients: A Single-Center Retrospective Cohort Study. (Pubmed Abstract) Authors Thom R, Bui M, Rosner B, Teslyar P, Levy-Carrick N, Wolfe D, Klompas M

Reply to Al-Hasan and Justo. (Pubmed Abstract) Authors Kalil AC, Gilbert DN, Winslow DL, Masur H, Klompas M

Hospital Length of Stay With a Proactive Psychiatric Consultation Model in the Medical Intensive Care Unit: A Prospective Cohort Analysis. (Pubmed Abstract) Authors Bui M, Thom RP, Hurwitz S, Levy-Carrick NC, O'Reilly M, Wilensky D, Talmasov D, Blanchfield B, Vaidya V, Kakoza R, Klompas M, Stanley E, Gitlin D, Massaro A

Difficult-to-Treat Resistance in Gram-negative Bacteremia at 173 US Hospitals: Retrospective Cohort Analysis of Prevalence, Predictors, and Outcome of Resistance to All First-line Agents. (Pubmed Abstract) Authors Kadri SS, Adjemian J, Lai YL, Spaulding AB, Ricotta E, Prevots DR, Palmore TN, Rhee C, Klompas M, Dekker JP, Powers JH, Suffredini AF, Hooper DC, Fridkin S, Danner RL,

Trends in "usual care" for septic shock. (Pubmed Abstract) Authors Hume PS, Varon J, Englert JA, Hurwitz S, Klompas M, Baron RM, Rhee C

Compliance With the National SEP-1 Quality Measure and Association With Sepsis Outcomes: A Multicenter Retrospective Cohort Study. (Pubmed Abstract) Authors Rhee C, Filbin MR, Massaro AF, Bulger AL, McEachern D, Tobin KA, Kitch BT, Thurlo-Walsh B, Kadar A, Koffman A, Pande A, Hamad Y, Warren DK, Jones TM, O'Brien C, Anderson DJ, Wang R, Klompas M,

Variability in determining sepsis time zero and bundle compliance rates for the centers for medicare and medicaid services SEP-1 measure. (Pubmed Abstract) Authors Rhee C, Brown SR, Jones TM, O'Brien C, Pande A, Hamad Y, Bulger AL, Tobin KA, Massaro AF, Anderson DJ, Warren DK, Klompas M,

Rethinking Ventilator Bundles. (Pubmed Abstract) Authors Klompas M, Kalil AC

Oral care with chlorhexidine: beware! (Pubmed Abstract) Authors Bouadma L, Klompas M

Missed Opportunities for Better Sepsis Care or Misplaced Blame? Deconstructing Patients' Encounters in the Week Before Sepsis Hospitalizations. (Pubmed Abstract) Authors Klompas M, Rhee C

Quality measurement forinfection: turning lemons into lemonade. (Pubmed Abstract) Authors Pimentel MP, Klompas M, Kachalia A

Quality measurement forinfection: turning lemons into lemonade. (Pubmed Abstract) Authors Pimentel MP, Klompas M, Kachalia A

Missed Opportunities for Better Sepsis Care or Misplaced Blame? Deconstructing Patients' Encounters in the Week Before Sepsis Hospitalizations. (Pubmed Abstract) Authors Klompas M, Rhee C

Vive la difference! France's new guidelines on hospital-acquired pneumonia. (Pubmed Abstract) Authors Klompas M

Genomics of Corynebacterium striatum, an emerging multi-drug resistant pathogen of immunocompromised patients. (Pubmed Abstract) Authors Nudel K, Zhao X, Basu S, Dong X, Hoffmann M, Feldgarden M, Allard M, Klompas M, Bry L

Genomics of Corynebacterium striatum, an emerging multi-drug resistant pathogen of immunocompromised patients. (Pubmed Abstract) Authors Nudel K, Zhao X, Basu S, Dong X, Hoffmann M, Feldgarden M, Allard M, Klompas M, Bry L

Ceftazidime-avibactam versus meropenem for the treatment of nosocomial pneumonia. (Pubmed Abstract) Authors Kalil AC, Klompas M

IDSA POSITION STATEMENT: Why IDSA Did Not Endorse the Surviving Sepsis Campaign Guidelines. (Pubmed Abstract) Authors Gilbert DN, Kalil AC, Klompas M, Masur H, Winslow DL

Ventilator-Associated Events 5 Years Later. (Pubmed Abstract) Authors Klompas M

Factors Associated With Pediatric Ventilator-Associated Conditions in Six U.S. Hospitals: A Nested Case-Control Study. (Pubmed Abstract) Authors Cocoros NM, Priebe G, Gray JE, Toltzis P, Larsen GY, Logan LK, Coffin S, Sammons JS, Deakins K, Horan K, Lakoma M, Young J, Burton M, Klompas M, Lee GM

Incidence and Trends of Sepsis in US Hospitals Using Clinical vs Claims Data, 2009-2014. (Pubmed Abstract) Authors Rhee C, Dantes R, Epstein L, Murphy DJ, Seymour CW, Iwashyna TJ, Kadri SS, Angus DC, Danner RL, Fiore AE, Jernigan JA, Martin GS, Septimus E, Warren DK, Karcz A, Chan C, Menchaca JT, Wang R, Gruber S, Klompas M,

Incidence and Trends of Sepsis in US Hospitals Using Clinical vs Claims Data, 2009-2014. (Pubmed Abstract) Authors Rhee C, Dantes R, Epstein L, Murphy DJ, Seymour CW, Iwashyna TJ, Kadri SS, Angus DC, Danner RL, Fiore AE, Jernigan JA, Martin GS, Septimus E, Warren DK, Karcz A, Chan C, Menchaca JT, Wang R, Gruber S, Klompas M,

Monotherapy Is Adequate for Septic Shock Due to Gram-Negative Organisms. (Pubmed Abstract) Authors Klompas M

What Is the National Burden of Sepsis in U.S. Emergency Departments? It Depends on the Definition. (Pubmed Abstract) Authors Rhee C, Klompas M

What Is the National Burden of Sepsis in U.S. Emergency Departments? It Depends on the Definition. (Pubmed Abstract) Authors Rhee C, Klompas M AbbreviationCrit. Care Med. Volume45 Issue9 Publication Date2017-08-20 What is new in the prevention of nosocomial pneumonia in the ICU? (Pubmed Abstract) Authors Klompas M

State and Local Chronic Disease Surveillance Using Electronic Health Record Systems. (Pubmed Abstract) Authors Klompas M, Cocoros NM, Menchaca JT, Erani D, Hafer E, Herrick B, Josephson M, Lee M, Payne Weiss MD, Zambarano B, Eberhardt KR, Malenfant J, Nasuti L, Land T

State and Local Chronic Disease Surveillance Using Electronic Health Record Systems. (Pubmed Abstract) Authors Klompas M, Cocoros NM, Menchaca JT, Erani D, Hafer E, Herrick B, Josephson M, Lee M, Payne Weiss MD, Zambarano B, Eberhardt KR, Malenfant J, Nasuti L, Land T

New Sepsis and Septic Shock Definitions: Clinical Implications and Controversies. (Pubmed Abstract) Authors Rhee C, Klompas M

Evolving insights into the epidemiology and control of Clostridium difficile in hospitals. (Pubmed Abstract) Authors Caroff DA, Yokoe DS, Klompas M

Two-State Collaborative Study of a Multifaceted Intervention to Decrease Ventilator-Associated Events. (Pubmed Abstract) Authors Rawat N, Yang T, Ali KJ, Catanzaro M, Cohen MD, Farley DO, Lubomski LH, Thompson DA, Winters BD, Cosgrove SE, Klompas M, Speck KA, Berenholtz SM

Changes in Rates of Ventilator-Associated Pneumonia-Reply. (Pubmed Abstract) Authors Metersky ML, Klompas M, Eldridge N

Beware the siren's song of novel endotracheal tube designs. (Pubmed Abstract) Authors Klompas M, Berra L, Branson R

Ultra short course antibiotics for patients with suspected ventilator-associated pneumonia but minimal and stable ventilator settings. (Pubmed Abstract) Authors Klompas M, Li L, Menchaca JT, Gruber S,

A Pediatric Approach to Ventilator-Associated Events Surveillance. (Pubmed Abstract) Authors Cocoros NM, Priebe GP, Logan LK, Coffin S, Larsen G, Toltzis P, Sandora TJ, Harper M, Sammons JS, Gray JE, Goldmann D, Horan K, Burton M, Checchia PA, Lakoma M, Sims S, Klompas M, Lee GM